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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Merrill Smith | 165 | 1975-1989 | |
| 2 | Sterling Patterson | 93 | 1946-1955 | |
| 2 | Harold Williams | 93 | 1963-1974 | |
| 4 | Nate Wise | 88 | 1913-1919 | |
| 5 | Andreas Aaberg | 79 | 1961-1966 | |
| 6 | Hanus Huml | 70 | 1945-1953 | |
| 7 | Kyuso Otsuka | 69 | 1914-1919 | |
| 8 | Len Jackson# | 67 | 1982-1991 | |
| 9 | Jon McMichael | 62 | 1911-1918 | |
| 10 | Sepp Kiemlen | 57 | 1934-1945 | |
| 11 | Ángel Aponte | 56 | 1975-1978 | |
| 12 | Artie Baucom | 55 | 1959-1966 | |
| 13 | Doug Nelson | 51 | 1911-1911 | |
| 14 | Jesús Muñóz | 48 | 1936-1946 | |
| 14 | Yifter Olushegun | 48 | 1979-1987 | |
| 16 | Jesús Peña | 47 | 1944-1954 | |
| 16 | Francisco Ramos | 47 | 1933-1940 | |
| 18 | Enrique Diéguez# | 46 | 1987-1991 | |
| 18 | Bobby Green | 46 | 1916-1922 | |
| 20 | Matt Brown | 45 | 1911-1914 | |
| 20 | Puck Huijbregts | 45 | 1976-1985 | |
| 22 | Francisco Fernández | 43 | 1962-1966 | |
| 22 | Ramón Vega | 43 | 1962-1965 | |
| 24 | Steve Murphy | 42 | 1911-1914 | |
| 25 | Héctor Martínez | 41 | 1963-1966 | |
| 25 | Arturo Reyna | 41 | 1958-1960 | |
| 27 | Gray Akerval | 40 | 1970-1977 | |
| 27 | Monte Brando | 40 | 1968-1974 | |
| 27 | Desmond Logan Jr. | 40 | 1957-1964 | |
| 27 | Enrique López | 40 | 1949-1954 | |
| 31 | Eugene Henderson | 39 | 1967-1978 | |
| 31 | Bruce Weir | 39 | 1913-1918 | |
| 33 | Félix Castillo | 37 | 1955-1962 | |
| 33 | Héctor Rodríguez | 37 | 1952-1958 | |
| 35 | Larry Carey | 36 | 1946-1958 | |
| 35 | António Guerra | 36 | 1962-1971 | |
| 35 | Germán Ramírez | 36 | 1911-1913 | |
| 38 | Vicente Aguilera | 35 | 1912-1916 | |
| 38 | Colm Gallie# | 35 | 1987-1990 | |
| 38 | Steve McLaughlin | 35 | 1954-1965 | |
| 41 | Kevin Burton# | 34 | 1982-1985 | |
| 41 | Michael Halliburton | 34 | 1917-1919 | |
| 41 | Tommy Rigsby | 34 | 1961-1978 | |
| 44 | António Aguilar | 33 | 1949-1956 | |
| 44 | Johan Guildenstern | 33 | 1933-1939 | |
| 44 | Víctor Padilla | 33 | 1914-1918 | |
| 44 | Ruslan Tagiyev# | 33 | 1980-1982 | |
| 48 | Mike Anderson | 32 | 1968-1984 | |
| 48 | Kalule Rassul | 32 | 1919-1928 | |
| 50 | Kevin Brown# | 31 | 1986-1990 | |
| 50 | José Medina | 31 | 1953-1961 | |
| 52 | Jerry Bryant | 30 | 1937-1946 | |
| 52 | François Couturier | 30 | 1934-1940 | |
| 54 | Hughie Churches# | 29 | 1987-1991 | |
| 54 | Tommy Gove | 29 | 1958-1966 | |
| 54 | Viggo Knudsen | 29 | 1915-1923 | |
| 54 | Carlos Páez# | 29 | 1986-1988 | |
| 54 | Armando Reyes | 29 | 1916-1926 | |
| 54 | Dan Walls | 29 | 1977-1983 | |
| 54 | Matt Zimmerman | 29 | 1911-1913 | |
| 61 | Benjamin Blanc | 28 | 1915-1917 | |
| 61 | Marcos Fernández | 28 | 1969-1981 | |
| 61 | Leonard West | 28 | 1911-1911 | |
| 64 | Emílio Alvarado | 27 | 1913-1924 | |
| 64 | José Andrade | 27 | 1950-1961 | |
| 64 | Gilberto Cruz | 27 | 1978-1979 | |
| 64 | Casey Dickson | 27 | 1911-1913 | |
| 64 | Tony Duckworth | 27 | 1934-1942 | |
| 64 | António Gómez# | 27 | 1982-1985 | |
| 64 | Javier López | 27 | 1970-1976 | |
| 71 | Steven Bennett | 26 | 1921-1933 | |
| 71 | Ed Bush | 26 | 1913-1921 | |
| 71 | José Delmoral | 26 | 1915-1922 | |
| 71 | Joe Hess | 26 | 1977-1985 | |
| 71 | Mei Zang | 26 | 1912-1915 | |
| 76 | Brad Banks | 25 | 1912-1914 | |
| 76 | Rick Cook | 25 | 1962-1966 | |
| 76 | Amado Jaramillo | 25 | 1935-1941 | |
| 79 | Armando Cabrera | 24 | 1983-1990 | |
| 79 | César García# | 24 | 1977-1979 | |
| 79 | Wen-hua Lundgren | 24 | 1940-1952 | |
| 79 | Reynaldo Ortíz | 24 | 1927-1933 | |
| 83 | Jeff Giles | 23 | 1955-1961 | |
| 83 | Melvin Lewis | 23 | 1966-1969 | |
| 83 | Norberto Rodríguez | 23 | 1913-1917 | |
| 83 | Johannes Trommler | 23 | 1975-1975 | |
| 87 | Cecil Carter | 22 | 1959-1961 | |
| 87 | Makoto Okamoto# | 22 | 1982-1989 | |
| 87 | R.J. Rafuse | 22 | 1940-1946 | |
| 90 | Ramón Borges# | 21 | 1988-1990 | |
| 90 | Ricardo Fuentes | 21 | 1944-1947 | |
| 90 | Milo MacPherson# | 21 | 1984-1988 | |
| 90 | John Peters | 21 | 1912-1916 | |
| 90 | Jason Sullivan | 21 | 1912-1915 | |
| 95 | Paco Aragón# | 20 | 1983-1991 | |
| 95 | Inaki Auwina | 20 | 1949-1951 | |
| 95 | José García | 20 | 1957-1962 | |
| 95 | Rafael García | 20 | 1949-1953 | |
| 95 | Jorge López | 20 | 1966-1969 | |
| 95 | Ronnie Moore | 20 | 1952-1955 |
