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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | William Brooks | 0.735 | 1950 | |
| 2 | Elwood Wan# | 1.202 | 1984 | |
| 3 | Lou Fletcher | 1.258 | 1915 | |
| 4 | Pedro Montés | 1.278 | 1949 | |
| 5 | Justin Sutton | 1.290 | 1969 | |
| 6 | Frederico Martínez | 1.385 | 1966 | |
| 7 | Pedro Lugo | 1.400 | 1964 | |
| 8 | Samuel Jackson | 1.412 | 1966 | |
| 9 | Morris Gunther | 1.457 | 1918 | |
| 10 | Jorge Rosado | 1.475 | 1975 | |
| 11 | Fath Mus'ad | 1.476 | 1975 | |
| 12 | Javier Madrigal | 1.489 | 1961 | |
| 13 | Chris Watson | 1.532 | 1918 | |
| 14 | Bob Burke | 1.533 | 1966 | |
| 15 | Pedro Rivera | 1.558 | 1945 | |
| 16 | Miguel Mendoza# | 1.574 | 1989 | |
| 17 | Esteban Soto | 1.582 | 1970 | |
| 18 | Carlos Carrillo | 1.624 | 1986 | |
| 19 | Hector Guerrieri | 1.625 | 1983 | |
| 20 | Don Olsen | 1.653 | 1933 | |
| 21 | Francisco Cruz | 1.660 | 1961 | |
| 22 | Francisco García | 1.688 | 1965 | |
| 23 | Vince Carson | 1.699 | 1950 | |
| 24 | Luis Díaz | 1.709 | 1974 | |
| 25 | António Álvarez# | 1.761 | 1981 | |
| 26 | Stan Dennis | 1.773 | 1918 | |
| 27 | Barney Mullins | 1.776 | 1988 | |
| 28 | Bartolo Russo | 1.784 | 1950 | |
| 29 | Héctor Cabrera | 1.791 | 1968 | |
| 30 | Floyd Olson | 1.793 | 1950 | |
| 31 | José García# | 1.800 | 1983 | |
| 32 | Frank Sanford | 1.805 | 1919 | |
| 33 | Wahid bin Yasin | 1.841 | 1984 | |
| 34 | Derek Bridges# | 1.843 | 1988 | |
| 35 | Roberto López | 1.854 | 1950 | |
| 35 | Nicholas Cassidy | 1.854 | 1974 | |
| 37 | John López | 1.855 | 1986 | |
| 38 | Martin Clark | 1.891 | 1932 | |
| 39 | Mende Aljeroz# | 1.896 | 1974 | |
| 40 | Stewart Carter | 1.934 | 1961 | |
| 41 | Emílio Nájera | 1.962 | 1926 | |
| 42 | Yoshimatsu Kumatani# | 1.974 | 1977 | |
| 43 | Woodrow Davis* | 2.000 | 1959 | |
| 44 | Lorenzo Delgado | 2.004 | 1962 | |
| 44 | Gavin Miller | 2.004 | 1918 | |
| 46 | Chris Sims | 2.013 | 1924 | |
| 47 | Felipe Franco | 2.014 | 1956 | |
| 48 | Jacob Kirkland# | 2.015 | 1986 | |
| 49 | Jesús Alvarado | 2.022 | 1957 | |
| 50 | J.R. George | 2.025 | 1956 | |
| 51 | John Fowler | 2.028 | 1919 | |
| 52 | Jorge Muñóz# | 2.038 | 1985 | |
| 52 | Andy Gilbert | 2.038 | 1963 | |
| 54 | Jian-gun Chew | 2.047 | 1956 | |
| 54 | Ed Hull | 2.047 | 1918 | |
| 56 | Ramón García# | 2.048 | 1983 | |
| 57 | Gustavo Miranda# | 2.053 | 1984 | |
| 58 | Ricciardo Musante | 2.061 | 1961 | |
| 59 | José Ortíz | 2.077 | 1984 | |
| 59 | Ernie Burgess | 2.077 | 1958 | |
| 59 | Ezra McCreight# | 2.077 | 1986 | |
| 62 | Urs Oversluizen | 2.092 | 1969 | |
| 63 | Jorge Fernández | 2.105 | 1967 | |
| 64 | Sonny Lawrence | 2.113 | 1966 | |
| 64 | Brad Johnson | 2.113 | 1965 | |
| 66 | Brad Britt# | 2.119 | 1984 | |
| 67 | Blake Johnson | 2.139 | 1964 | |
| 68 | Cris Ramos | 2.148 | 1921 | |
| 69 | José González | 2.152 | 1976 | |
| 70 | Sugimoto Kato# | 2.155 | 1985 | |
| 71 | Vincent McGee# | 2.160 | 1987 | |
| 72 | Donald Kavur | 2.163 | 1980 | |
| 72 | Bryant Morton | 2.163 | 1980 | |
| 74 | Okura Takahashi | 2.181 | 1962 | |
| 75 | Junji Ono# | 2.195 | 1985 | |
| 76 | John Jones | 2.197 | 1933 | |
| 77 | Josh Jenkins | 2.207 | 1918 | |
| 78 | Júlio Orozco | 2.209 | 1958 | |
| 79 | José Ortíz | 2.215 | 1983 | |
| 80 | Jakob Astrup | 2.221 | 1949 | |
| 81 | Jorge Otero# | 2.228 | 1984 | |
| 82 | Okura Ichihara | 2.229 | 1954 | |
| 83 | Derrick Elliott | 2.230 | 1972 | |
| 84 | Maikel Kranendonk | 2.233 | 1933 | |
| 85 | Colin Davis | 2.243 | 1950 | |
| 86 | Eric Wood# | 2.250 | 1975 | |
| 87 | Francisco Pacheco | 2.262 | 1964 | |
| 88 | Domingo Jáquez# | 2.274 | 1979 | |
| 89 | Francisco Trujillo | 2.276 | 1965 | |
| 90 | Jian-gun Chew | 2.278 | 1955 | |
| 91 | Ramón Márquez | 2.280 | 1949 | |
| 92 | Alistair Hou | 2.282 | 1963 | |
| 93 | Héctor Cabrera | 2.283 | 1969 | |
| 94 | Gerardo Fei | 2.292 | 1956 | |
| 95 | Manuel Guerrero# | 2.300 | 1989 | |
| 96 | Octávio Luna | 2.301 | 1980 | |
| 97 | Damon Boggs# | 2.304 | 1982 | |
| 98 | Joe Olson | 2.306 | 1962 | |
| 99 | Jesús Perea | 2.310 | 1950 | |
| 100 | Ron Duncan | 2.312 | 1956 |
