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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Brian Buck | 87 | 1966-1971 | |
| 1 | Adam Meadowes | 87 | 1911-1914 | |
| 3 | Ed Carpenter | 85 | 1955-1960 | |
| 4 | Valentín López | 80 | 1912-1914 | |
| 5 | William Piper | 79 | 1953-1957 | |
| 6 | Esteban Méndez | 75 | 1970-1974 | |
| 7 | Ryan Howe | 74 | 1978-1982 | |
| 8 | Phil Ryan | 71 | 1927-1930 | |
| 9 | Francisco García | 70 | 1912-1915 | |
| 10 | Jason Retter# | 69 | 1975-1990 | |
| 11 | Mark Mitchell | 68 | 1951-1954 | |
| 12 | Ernesto Caboverde | 67 | 1947-1950 | |
| 12 | Ray Hopkins | 67 | 1972-1978 | |
| 14 | Gustavo Mercado | 66 | 1960-1966 | |
| 15 | Javier Hernández# | 65 | 1983-1990 | |
| 16 | César Anaya | 64 | 1976-1981 | |
| 16 | Tony Romano | 64 | 1956-1960 | |
| 18 | Daron Gilmore | 63 | 1976-1983 | |
| 18 | Ricardo Ransom | 63 | 1914-1916 | |
| 20 | Loren Leonard | 62 | 1912-1915 | |
| 21 | Paul Hicks | 61 | 1974-1979 | |
| 21 | Rubén Ramos | 61 | 1980-1984 | |
| 23 | Morris Gunther | 60 | 1914-1917 | |
| 24 | Ted Cannon | 59 | 1961-1964 | |
| 24 | Joe Larsen | 59 | 1965-1967 | |
| 26 | Rudy Campbell# | 58 | 1980-1986 | |
| 26 | Phil Garza | 58 | 1974-1980 | |
| 26 | Orlando Guillén | 58 | 1977-1985 | |
| 26 | Fiorello Recchi | 58 | 1959-1963 | |
| 30 | Ralph Schultz | 57 | 1956-1961 | |
| 30 | Michael Stephenson | 57 | 1976-1985 | |
| 32 | Phil Campbell | 56 | 1950-1954 | |
| 32 | Charles Fontenot | 56 | 1912-1915 | |
| 32 | Raúl Hernández | 56 | 1933-1936 | |
| 32 | Cal Jackson | 56 | 1913-1915 | |
| 32 | Rafael Serrano | 56 | 1975-1988 | |
| 37 | Mike Miller | 55 | 1912-1915 | |
| 37 | Alexis Thomas# | 55 | 1976-1980 | |
| 37 | Alonso Zumaya | 55 | 1978-1985 | |
| 40 | Frank Barbour | 54 | 1953-1955 | |
| 41 | Jon Harris | 53 | 1975-1978 | |
| 41 | Leo Mcdonald | 53 | 1975-1981 | |
| 41 | Tony Morín# | 53 | 1977-1989 | |
| 44 | Howard Albright | 52 | 1974-1977 | |
| 44 | Jimmy Simons | 52 | 1940-1942 | |
| 44 | Harris Smith | 52 | 1927-1931 | |
| 47 | Bob Carter | 51 | 1975-1978 | |
| 47 | Tokuhei Miyamoto | 51 | 1975-1979 | |
| 47 | Júlio Rentería | 51 | 1923-1925 | |
| 47 | José Rodríguez | 51 | 1956-1959 | |
| 47 | Patrick Tyler | 51 | 1972-1975 | |
| 52 | Paul Bray | 50 | 1938-1941 | |
| 52 | Riley Harley | 50 | 1941-1946 | |
| 52 | Charlie McBride | 50 | 1975-1976 | |
| 52 | Jong-beom Paek | 50 | 1933-1936 | |
| 56 | José Marino | 49 | 1914-1915 | |
| 56 | Jesús Muńóz | 49 | 1952-1956 | |
| 58 | Enrique Barrios* | 48 | 1941-1943 | |
| 58 | Jean-François Faure | 48 | 1975-1979 | |
| 58 | Pedro Fernández | 48 | 1912-1914 | |
| 58 | José Flores | 48 | 1962-1964 | |
| 58 | Don Lord | 48 | 1975-1981 | |
| 58 | Gary Powers | 48 | 1983-1988 | |
| 58 | Pascual Trejo | 48 | 1960-1968 | |
| 58 | Jorge Valdés | 48 | 1934-1936 | |
| 66 | Ángel Medima | 47 | 1976-1978 | |
| 66 | Rafael Moreno | 47 | 1962-1964 | |
| 66 | César Olvera | 47 | 1934-1938 | |
| 66 | Rafael Wiley | 47 | 1963-1969 | |
| 70 | David Brown | 46 | 1974-1978 | |
| 70 | Manuel González | 46 | 1973-1977 | |
| 70 | Lorenzo López | 46 | 1971-1975 | |
| 73 | António Baca | 45 | 1942-1945 | |
| 73 | Ippei Hashimoto | 45 | 1975-1976 | |
| 73 | Rick Malone | 45 | 1911-1914 | |
| 73 | Esteban Rey | 45 | 1956-1960 | |
| 77 | Curt Ferguson | 44 | 1912-1914 | |
| 77 | Tony García# | 44 | 1981-1984 | |
| 77 | Oliver Morales | 44 | 1929-1931 | |
| 77 | Cliff Spronk | 44 | 1954-1957 | |
| 77 | Alonso Torres | 44 | 1959-1965 | |
| 77 | Zach Wallace | 44 | 1952-1956 | |
| 83 | Medardo Calhamar | 43 | 1980-1990 | |
| 83 | Jimmy Lamb | 43 | 1938-1947 | |
| 83 | Bart Nicholas | 43 | 1915-1918 | |
| 83 | Jesús Rentería# | 43 | 1979-1984 | |
| 83 | Pedro Rosas | 43 | 1972-1976 | |
| 83 | Tim Sherston | 43 | 1915-1918 | |
| 83 | Ignacio Valdéz | 43 | 1912-1914 | |
| 90 | Wallace Melville | 42 | 1914-1916 | |
| 91 | Santiago Guerrero | 41 | 1967-1971 | |
| 91 | Hubert Moore | 41 | 1964-1968 | |
| 91 | Joe Olson | 41 | 1957-1960 | |
| 91 | Duane Peck | 41 | 1931-1936 | |
| 91 | António Romero | 41 | 1973-1976 | |
| 91 | Juan Jose Sánchez | 41 | 1947-1949 | |
| 91 | Jing-xiang Woo# | 41 | 1982-1989 | |
| 98 | Ramiro Bruno | 40 | 1936-1940 | |
| 98 | José Escobar | 40 | 1962-1963 | |
| 98 | Denilde Espadinha | 40 | 1983-1989 |
