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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Vicente Cisneros | 0.500 | 1923 | |
| 2 | Esteban Bañuelos | 0.952 | 1923 | |
| 3 | Greg Burkett | 1.378 | 1918 | |
| 4 | Brandon Lindsey | 1.421 | 1919 | |
| 5 | Tim Brown | 1.426 | 1920 | |
| 6 | Esteban Duarte | 1.500 | 1925 | |
| 7 | Granville Quick | 1.521 | 1926 | |
| 8 | Mal Wright | 1.530 | 1919 | |
| 9 | Roberto Campos | 1.627 | 1924 | |
| 10 | Gerrie Luby | 1.688 | 1925 | |
| 10 | Tom Zúñiga | 1.688 | 1922 | |
| 12 | Edwin van Pelt | 1.702 | 1924 | |
| 13 | Francisco García | 1.708 | 1923 | |
| 14 | Barry Smith | 1.770 | 1926 | |
| 15 | Alfredo Hernández | 1.806 | 1924 | |
| 16 | Truman Robertson | 1.829 | 1919 | |
| 17 | Mitchell Blevins | 1.837 | 1921 | |
| 18 | Brandon Lindsey | 1.853 | 1918 | |
| 19 | Tony Torres | 1.860 | 1918 | |
| 20 | Simon Gilbert | 1.869 | 1940 | |
| 21 | Fernando Flores | 1.888 | 1925 | |
| 22 | Greg Burkett | 1.895 | 1919 | |
| 23 | Máximo Hernández | 1.900 | 1943 | |
| 24 | Harvey Stanley | 1.914 | 1919 | |
| 25 | Tim Sherston | 1.929 | 1918 | |
| 26 | David Joseph | 1.947 | 1924 | |
| 27 | Truman Robertson | 1.962 | 1918 | |
| 28 | John Rhodes | 1.965 | 1919 | |
| 29 | Calvin Walker | 1.973 | 1926 | |
| 30 | Luis Silva | 1.996 | 1918 | |
| 31 | Bart Nicholas | 2.003 | 1918 | |
| 32 | Francisco Bueno | 2.051 | 1932 | |
| 33 | Patrick Hughes | 2.052 | 1924 | |
| 34 | Kosho Yamasaki# | 2.077 | 1986 | |
| 35 | Charles Fontenot | 2.086 | 1914 | |
| 36 | John Aastrom | 2.108 | 1934 | |
| 37 | Bartolo González | 2.135 | 1921 | |
| 38 | Ellis Masters | 2.148 | 1920 | |
| 39 | Carlos Casteneda | 2.150 | 1929 | |
| 40 | Pancho García | 2.160 | 1943 | |
| 41 | Hai-dong Wang | 2.163 | 1921 | |
| 42 | Mike Miller | 2.168 | 1914 | |
| 43 | Mark Thurman | 2.177 | 1920 | |
| 44 | Onne Vis | 2.183 | 1925 | |
| 45 | Marcos Alonso | 2.187 | 1922 | |
| 46 | Marcos Alonso | 2.194 | 1921 | |
| 47 | Stuart Wu | 2.225 | 1926 | |
| 48 | Tony Torres | 2.238 | 1919 | |
| 49 | John Rhodes | 2.250 | 1918 | |
| 50 | Cipriano Castro | 2.266 | 1987 | |
| 51 | Jorge Oliva | 2.274 | 1943 | |
| 52 | Alejandro Torres | 2.282 | 1917 | |
| 52 | Molloy Riseborough | 2.282 | 1943 | |
| 54 | José Juárez | 2.302 | 1945 | |
| 55 | Sean Elder | 2.308 | 1918 | |
| 55 | Trofimoff Goncharik | 2.308 | 1978 | |
| 57 | Tom Bennett | 2.311 | 1918 | |
| 58 | Álex López | 2.312 | 1926 | |
| 59 | Eduardo Delpino# | 2.320 | 1986 | |
| 59 | Erwin Stuy | 2.320 | 1923 | |
| 61 | Nick English | 2.332 | 1961 | |
| 62 | Nicholas Pitts# | 2.339 | 1986 | |
| 63 | Adolf Andone | 2.357 | 1923 | |
| 64 | Il-hwan P'aeng | 2.362 | 1919 | |
| 65 | Chris Bastien | 2.392 | 1936 | |
| 66 | Tristan Robillard | 2.440 | 1979 | |
| 67 | Domingo Rosário | 2.463 | 1928 | |
| 68 | Bartolo González | 2.488 | 1922 | |
| 68 | Woody Coleman# | 2.488 | 1970 | |
| 70 | Elwood Walker | 2.489 | 1966 | |
| 71 | Juan Mendoza | 2.491 | 1924 | |
| 71 | Charlie Rogers | 2.491 | 1932 | |
| 73 | Héctor Romero | 2.492 | 1969 | |
| 74 | Eugene Blair | 2.502 | 1947 | |
| 75 | Robby Lang | 2.522 | 1948 | |
| 76 | Kevin Rhodes | 2.528 | 1931 | |
| 77 | George Koch | 2.545 | 1981 | |
| 78 | Borek Jerksak | 2.547 | 1947 | |
| 79 | Pedro Pérez | 2.576 | 1919 | |
| 80 | Phil Edwards | 2.582 | 1944 | |
| 81 | Jesús López | 2.617 | 1927 | |
| 81 | Ricco Properzi | 2.617 | 1929 | |
| 83 | Josh Atkinson | 2.640 | 1925 | |
| 84 | Clint Watson | 2.646 | 1921 | |
| 85 | Sam George | 2.647 | 1920 | |
| 86 | Louie Batt | 2.662 | 1965 | |
| 87 | Philippe Mathieu | 2.673 | 1978 | |
| 88 | Egidius Leffler | 2.690 | 1930 | |
| 89 | Tony Galván | 2.691 | 1930 | |
| 90 | Sam Marshall | 2.700 | 1929 | |
| 91 | Luis Mariona | 2.712 | 1924 | |
| 91 | Ano Meresmaa | 2.712 | 1989 | |
| 91 | Rick O'Bryan | 2.712 | 1944 | |
| 91 | Claudio Martínez | 2.712 | 1926 | |
| 95 | Truman Robertson | 2.750 | 1917 | |
| 96 | Jesús Estrada | 2.754 | 1947 | |
| 97 | Paul Smith | 2.755 | 1915 | |
| 98 | David Ramírez | 2.765 | 1917 | |
| 99 | Jesús Cabada | 2.769 | 1944 | |
| 100 | Luis Mariona | 2.776 | 1923 |
