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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Campbell van Kooten | 3.347 | 1925-1929 | |
| 2 | José Hurtado | 3.463 | 1927-1933 | |
| 3 | Neil Bernard | 3.471 | 1939-1948 | |
| 4 | Bob Montalbetti | 3.482 | 1921-1933 | |
| 5 | Gabriel Garza | 3.506 | 1941-1950 | |
| 6 | Carlos Prieto | 3.567 | 1929-1934 | |
| 7 | Dennis Brouwers | 3.570 | 1919-1934 | |
| 8 | Scott Ashe | 3.588 | 1918-1923 | |
| 9 | Paul Lalonde | 3.591 | 1913-1920 | |
| 10 | Jesús Béltre | 3.600 | 1921-1927 | |
| 11 | Wayne Manuel | 3.611 | 1933-1938 | |
| 12 | António López | 3.625 | 1917-1923 | |
| 13 | Leo Spokes | 3.688 | 1919-1927 | |
| 14 | Michael Washington | 3.716 | 1975-1984 | |
| 15 | José Canseco | 3.724 | 1924-1933 | |
| 16 | Aurelio Garza | 3.740 | 1929-1942 | |
| 17 | Gilberto Castagna | 3.758 | 1928-1937 | |
| 18 | Ray Muller | 3.762 | 1914-1922 | |
| 19 | Quentin Hasted | 3.788 | 1915-1924 | |
| 20 | Jesús Martínez | 3.792 | 1931-1941 | |
| 21 | Liam Weddle | 3.797 | 1911-1919 | |
| 22 | Kalervo Haavikko | 3.825 | 1928-1938 | |
| 23 | George Crowley | 3.837 | 1915-1923 | |
| 24 | Akim Rossi | 3.842 | 1960-1973 | |
| 25 | Paul Williams | 3.861 | 1926-1932 | |
| 26 | Antony Fingleson | 3.870 | 1921-1931 | |
| 27 | Vincente Bamentos | 3.910 | 1928-1937 | |
| 27 | Mario Durán | 3.910 | 1934-1947 | |
| 29 | Oliver Selkirk | 3.914 | 1916-1923 | |
| 30 | Alberto Quezada | 3.916 | 1969-1983 | |
| 31 | Yo Li | 3.933 | 1927-1938 | |
| 32 | Kinnard Pancefoot | 3.970 | 1924-1935 | |
| 33 | Jon Wilson | 3.993 | 1915-1920 | |
| 34 | Igram Verhoek | 4.008 | 1928-1939 | |
| 35 | Alfredo Benítez | 4.009 | 1924-1933 | |
| 36 | Griff Howey | 4.024 | 1924-1934 | |
| 37 | Jason Coombes | 4.025 | 1922-1930 | |
| 38 | Ricardo García | 4.042 | 1929-1937 | |
| 39 | Tokutomi Sugano | 4.044 | 1934-1940 | |
| 40 | Jake Arbuckle | 4.061 | 1919-1930 | |
| 41 | Augusto Almodovar | 4.070 | 1942-1951 | |
| 42 | Uqessun Jumba | 4.081 | 1974-1988 | |
| 43 | Javier Echevarría | 4.120 | 1936-1944 | |
| 44 | Roy Bulmer | 4.155 | 1944-1950 | |
| 45 | Gabriel Martínez | 4.187 | 1935-1943 | |
| 46 | Kenneth Bennerman | 4.193 | 1941-1950 | |
| 47 | George Stevens | 4.232 | 1977-1986 | |
| 48 | Alastair Grimes | 4.246 | 1919-1923 | |
| 49 | Joey Jackson | 4.248 | 1960-1969 | |
| 50 | Frank Helmer | 4.251 | 1914-1924 | |
| 51 | Josuke Watanabe | 4.252 | 1931-1938 | |
| 52 | Arthur Blumberg | 4.282 | 1931-1941 | |
| 52 | José Montoya | 4.282 | 1937-1945 | |
| 54 | Tilmão Romeira | 4.310 | 1922-1935 | |
| 55 | Jay Rundle | 4.322 | 1914-1919 | |
| 56 | Avery Cross | 4.332 | 1960-1968 | |
| 57 | León Morales | 4.350 | 1921-1925 | |
| 57 | Zander Golunski | 4.350 | 1937-1950 | |
| 59 | Wasi Esam | 4.355 | 1975-1989 | |
| 60 | Emerson Boyd | 4.376 | 1938-1947 | |
| 61 | Stan McIndoe | 4.397 | 1940-1947 | |
| 62 | Sixto Sánchez | 4.403 | 1938-1950 | |
| 63 | Max Lacoste | 4.422 | 1935-1942 | |
| 64 | Micah Hollington | 4.441 | 1949-1956 | |
| 65 | Wade Jonas | 4.470 | 1911-1919 | |
| 66 | Raffaele Ghislieri | 4.492 | 1936-1946 | |
| 67 | Armando Rea | 4.509 | 1937-1944 | |
| 68 | Raymond Denhardt | 4.554 | 1941-1950 | |
| 69 | Mauro Vargas | 4.568 | 1942-1953 | |
| 70 | Claudio Maes | 4.582 | 1928-1940 | |
| 71 | Junji Onodera | 4.585 | 1966-1977 | |
| 72 | Scott Portsmouth | 4.601 | 1958-1972 | |
| 73 | Clifton Scott | 4.603 | 1936-1950 | |
| 74 | Francisco García | 4.606 | 1975-1988 | |
| 75 | Ángel Arroyo | 4.659 | 1916-1921 | |
| 76 | Francisco García | 4.695 | 1939-1944 | |
| 77 | Luis Álvarez | 4.712 | 1959-1968 | |
| 78 | Guillermo Gutiérrez | 4.750 | 1956-1964 | |
| 79 | Hong-bo Wu | 4.768 | 1912-1923 | |
| 80 | Ben Jones | 4.824 | 1980-1986 | |
| 81 | Philippe Dupont | 4.851 | 1913-1923 | |
| 82 | Jon Tosewell | 4.871 | 1944-1953 | |
| 83 | Francisco Soto# | 4.892 | 1977-1989 | |
| 84 | Bryce Tessier | 4.896 | 1949-1955 | |
| 85 | Ramiro Márquez | 4.910 | 1943-1950 | |
| 86 | Blair Lamond | 4.933 | 1925-1936 | |
| 87 | Arnie Park# | 4.935 | 1983-1990 | |
| 88 | Yin-xiang Jin# | 4.940 | 1975-1986 | |
| 89 | Toshikuni Mizuno | 4.961 | 1963-1969 | |
| 90 | Ron Farnell | 4.987 | 1914-1920 | |
| 91 | Tommy Richardson | 5.002 | 1984-1989 | |
| 92 | Nicholas Cassidy | 5.007 | 1979-1989 | |
| 93 | Colm Penwarden | 5.051 | 1959-1969 | |
| 94 | Miroslav Fleming | 5.088 | 1982-1989 | |
| 95 | Ted Fritz | 5.128 | 1963-1969 | |
| 96 | Christophe Besson | 5.167 | 1956-1968 | |
| 97 | Matt Andersen# | 5.194 | 1976-1988 | |
| 98 | Takahashi Nii | 5.218 | 1923-1931 | |
| 99 | Frank Hui | 5.331 | 1946-1955 | |
| 100 | Emmanuel Marchand | 5.473 | 1945-1950 |
