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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Mark Boyce | 0.720 | 1958 | |
| 2 | Marvin White | 0.722 | 1954 | |
| 3 | Jason Sanders | 0.904 | 1953 | |
| 4 | José Fuentes | 1.125 | 1964 | |
| 5 | Francisco Rivera | 1.174 | 1973 | |
| 6 | Ben Jones | 1.212 | 1970 | |
| 7 | Marty Hensley* | 1.246 | 1952 | |
| 8 | Joe Todd# | 1.278 | 1981 | |
| 9 | Ryan Tinker | 1.342 | 1968 | |
| 10 | Luis Ortega | 1.367 | 1954 | |
| 11 | Johnny Downey | 1.436 | 1969 | |
| 12 | Andy Flowers* | 1.446 | 1959 | |
| 13 | Ignacio Palácios | 1.500 | 1955 | |
| 14 | José García | 1.523 | 1953 | |
| 15 | Freddy Rosado | 1.530 | 1960 | |
| 16 | Ignacio Palácios | 1.536 | 1957 | |
| 17 | Naomichi Ine | 1.543 | 1964 | |
| 18 | Anthony Moore | 1.551 | 1963 | |
| 19 | Bob Ball# | 1.579 | 1984 | |
| 20 | Ricardo Barrera# | 1.588 | 1986 | |
| 21 | Luis Ortega | 1.604 | 1953 | |
| 22 | Davis Ayliffe# | 1.605 | 1981 | |
| 23 | Raúl Jiménez | 1.611 | 1962 | |
| 24 | Francisco García | 1.640 | 1963 | |
| 25 | Nicholas Cassidy | 1.648 | 1970 | |
| 26 | Elliott Mathews | 1.651 | 1965 | |
| 27 | Hugo Brederode | 1.655 | 1965 | |
| 28 | Ken Wade# | 1.688 | 1991 | |
| 28 | Jeff Brown | 1.688 | 1958 | |
| 30 | Rod Johnston | 1.701 | 1961 | |
| 31 | Luis Torres | 1.702 | 1957 | |
| 32 | Jason Sanders | 1.725 | 1954 | |
| 33 | Joe Olson | 1.726 | 1954 | |
| 34 | Jim Davidson | 1.737 | 1915 | |
| 35 | Marty Hensley* | 1.738 | 1954 | |
| 36 | José Álvarez | 1.745 | 1963 | |
| 37 | Gene Lewis# | 1.747 | 1991 | |
| 38 | Yu-bao Zhào | 1.765 | 1961 | |
| 39 | Jorge Morán | 1.770 | 1956 | |
| 40 | Salvador Rivera# | 1.775 | 1978 | |
| 40 | Freddy Rosado | 1.775 | 1959 | |
| 42 | Steve Ferguson# | 1.782 | 1976 | |
| 43 | Andy Flowers* | 1.788 | 1958 | |
| 44 | Elliott Mathews | 1.792 | 1966 | |
| 45 | José García | 1.793 | 1954 | |
| 46 | Luis Ortega | 1.800 | 1956 | |
| 46 | Anthony Moore | 1.800 | 1961 | |
| 48 | Freddy Pérez | 1.806 | 1959 | |
| 49 | Todd Baldwin# | 1.829 | 1980 | |
| 50 | Humberto Dotti | 1.833 | 1948 | |
| 51 | Archie Farmer | 1.841 | 1964 | |
| 52 | Manuel Castaneda | 1.848 | 1950 | |
| 53 | Jimmy Bacon# | 1.862 | 1972 | |
| 54 | Sergio Vásquez | 1.869 | 1969 | |
| 55 | Rod Johnston | 1.875 | 1958 | |
| 56 | Jason West | 1.906 | 1954 | |
| 57 | Pablo Gil# | 1.912 | 1986 | |
| 58 | Travis Brown | 1.916 | 1963 | |
| 59 | Brandon Pare | 1.919 | 1918 | |
| 60 | Robert van Bladel | 1.929 | 1959 | |
| 60 | Jorge Ramírez | 1.929 | 1954 | |
| 62 | Tomás Vargas# | 1.940 | 1974 | |
| 63 | Jimmy Bacon# | 1.941 | 1974 | |
| 64 | Davis Short# | 1.952 | 1979 | |
| 65 | José García | 1.962 | 1956 | |
| 66 | Armando Rivera | 1.965 | 1921 | |
| 67 | Andy Johnson | 1.969 | 1952 | |
| 68 | Júlio Mayen# | 1.980 | 1987 | |
| 69 | Mike Boucher | 1.981 | 1970 | |
| 70 | David Estrada | 1.984 | 1963 | |
| 71 | Aubrey Gray# | 1.989 | 1981 | |
| 72 | Guillermo Hernández | 2.000 | 1968 | |
| 72 | Danny Meade | 2.000 | 1976 | |
| 74 | Cris Vilardebo# | 2.004 | 1983 | |
| 75 | Hugo Brederode | 2.007 | 1966 | |
| 76 | José Fuentes | 2.019 | 1963 | |
| 77 | Mike Boucher | 2.021 | 1972 | |
| 78 | Pat Miller | 2.036 | 1959 | |
| 79 | Robert Reese | 2.049 | 1913 | |
| 80 | Jeff Robertson# | 2.053 | 1979 | |
| 81 | Iván Mendoza# | 2.066 | 1991 | |
| 82 | Naomichi Ine | 2.084 | 1965 | |
| 82 | Travis Brown | 2.084 | 1961 | |
| 84 | Manuel Rey# | 2.088 | 1988 | |
| 85 | Ricardo Barrera# | 2.092 | 1988 | |
| 86 | Marty Hensley* | 2.099 | 1955 | |
| 87 | Hugo Brederode | 2.104 | 1968 | |
| 88 | George Boyle# | 2.114 | 1981 | |
| 89 | Sancho Hernández# | 2.125 | 1986 | |
| 90 | Chris Reynolds* | 2.129 | 1913 | |
| 91 | Mark Boyce | 2.139 | 1959 | |
| 92 | William Wilson# | 2.140 | 1979 | |
| 93 | Woodrow Davis* | 2.150 | 1955 | |
| 94 | Raúl Jiménez | 2.151 | 1966 | |
| 95 | Michael Cates | 2.155 | 1956 | |
| 96 | Manuel Castaneda | 2.170 | 1948 | |
| 97 | Leroy Beatty | 2.171 | 1955 | |
| 98 | José Ramos | 2.177 | 1968 | |
| 99 | Jim Morton* | 2.179 | 1963 | |
| 100 | Jesús Cortés | 2.183 | 1955 |
