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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Grant Schneider | 0.375 | 1948 | |
| 2 | Salvador Hernández | 0.439 | 1948 | |
| 3 | Rene Hruby | 0.563 | 1948 | |
| 4 | Iván Enríquez | 0.566 | 1948 | |
| 5 | Juan Rodríguez | 0.604 | 1948 | |
| 6 | Robert Ellison | 0.777 | 1948 | |
| 7 | Julián Rivera | 0.783 | 1948 | |
| 8 | Tom Lawson | 0.863 | 1948 | |
| 9 | Hugh Townsend# | 0.864 | 1989 | |
| 10 | Jesús Rodríguez | 1.000 | 1948 | |
| 11 | Brandon Crawford | 1.005 | 1968 | |
| 12 | Mario Babilo | 1.032 | 1948 | |
| 13 | Peter Long | 1.049 | 1970 | |
| 14 | Bob Todd | 1.059 | 1970 | |
| 15 | Charles Fontenot | 1.108 | 1912 | |
| 16 | Scott Gould | 1.145 | 1948 | |
| 17 | Ben Morgan# | 1.174 | 1976 | |
| 17 | Albert Álvarez# | 1.174 | 1983 | |
| 19 | Matt Binyon# | 1.183 | 1980 | |
| 20 | Salvador Rivera# | 1.191 | 1976 | |
| 21 | John Rogan | 1.204 | 1948 | |
| 22 | Jesús Dávila | 1.211 | 1980 | |
| 23 | Jesús Rentería# | 1.246 | 1976 | |
| 23 | George Boyle# | 1.246 | 1977 | |
| 25 | Cecil Everett | 1.250 | 1970 | |
| 26 | César Martínez# | 1.256 | 1973 | |
| 27 | Chuck Johnson | 1.266 | 1970 | |
| 28 | Jesse Bailey | 1.286 | 1948 | |
| 28 | Francisco Valenzuela | 1.286 | 1948 | |
| 28 | Javier Castillo | 1.286 | 1951 | |
| 31 | Heath Williams# | 1.295 | 1988 | |
| 32 | Jeff Edwards# | 1.320 | 1983 | |
| 33 | Jason Duncan | 1.321 | 1920 | |
| 34 | Rafael Arranz# | 1.324 | 1990 | |
| 35 | Todd Hull | 1.385 | 1930 | |
| 35 | Gerald Farrell | 1.385 | 1963 | |
| 37 | Claudio Magana# | 1.390 | 1991 | |
| 38 | Alejandro Canseco# | 1.392 | 1991 | |
| 39 | Gerald Farrell | 1.394 | 1961 | |
| 40 | Michael Richards# | 1.403 | 1980 | |
| 41 | Armando Méndez# | 1.432 | 1984 | |
| 42 | Ron Martin# | 1.436 | 1976 | |
| 43 | Dave Smith | 1.450 | 1948 | |
| 43 | Alfonso Domínguez# | 1.450 | 1987 | |
| 45 | Adrian Franklin | 1.477 | 1970 | |
| 46 | Tito Zanardi | 1.488 | 1916 | |
| 47 | Paul Whitehead# | 1.493 | 1981 | |
| 48 | Davey Dudley | 1.500 | 1965 | |
| 48 | Chris McNeal# | 1.500 | 1980 | |
| 48 | Heath Williams# | 1.500 | 1986 | |
| 48 | Felipe Sánchez | 1.500 | 1966 | |
| 52 | Mike Fisher# | 1.519 | 1990 | |
| 53 | Nick Johnston | 1.525 | 1984 | |
| 54 | Rubén Vázquez | 1.533 | 1969 | |
| 55 | Frank Barbour | 1.539 | 1958 | |
| 56 | Randall Davis# | 1.547 | 1981 | |
| 57 | Albert Giffning | 1.558 | 1959 | |
| 58 | José Martínez | 1.562 | 1938 | |
| 59 | Roderick Byrd# | 1.568 | 1971 | |
| 60 | Bill Patterson# | 1.571 | 1990 | |
| 60 | Francisco Cabrera | 1.571 | 1963 | |
| 62 | Albert McGill | 1.575 | 1969 | |
| 62 | Jake Worley# | 1.575 | 1988 | |
| 64 | Elwood Wan# | 1.577 | 1979 | |
| 65 | Jim Sullivan# | 1.578 | 1977 | |
| 66 | António García# | 1.579 | 1984 | |
| 67 | Juan Romero | 1.597 | 1965 | |
| 68 | Ron Stroud | 1.600 | 1924 | |
| 69 | Carlos Ibarra | 1.604 | 1970 | |
| 70 | Tanner Hayes | 1.614 | 1970 | |
| 71 | Barry Richard# | 1.618 | 1982 | |
| 72 | Carlos Gaona# | 1.620 | 1985 | |
| 73 | Jason Murdoch# | 1.636 | 1973 | |
| 73 | Andrew Payne# | 1.636 | 1991 | |
| 75 | Thomaz Granato | 1.643 | 1951 | |
| 76 | Tad Morgan | 1.646 | 1965 | |
| 77 | Brandon Crawford | 1.662 | 1965 | |
| 78 | Rodger Lawson# | 1.665 | 1980 | |
| 79 | António Hernández | 1.667 | 1965 | |
| 80 | Tom Muller | 1.671 | 1948 | |
| 81 | Michael Richards# | 1.679 | 1982 | |
| 82 | Alejandro Valentín# | 1.680 | 1978 | |
| 83 | Todd Skinner# | 1.688 | 1987 | |
| 83 | Whit Nash | 1.688 | 1948 | |
| 83 | Lorenzo López | 1.688 | 1970 | |
| 86 | Carlos Gonzáles# | 1.697 | 1979 | |
| 87 | Jorge Guillén# | 1.698 | 1988 | |
| 88 | Woody Coleman# | 1.701 | 1968 | |
| 89 | Tomás Reyes# | 1.705 | 1976 | |
| 90 | Merlin Miles | 1.711 | 1955 | |
| 91 | António Hernández | 1.716 | 1966 | |
| 92 | Paul Whitehead# | 1.723 | 1984 | |
| 93 | Von Murphy | 1.737 | 1967 | |
| 94 | Javier Navarro# | 1.742 | 1990 | |
| 95 | Júlio Cortéz | 1.748 | 1948 | |
| 96 | Artie Wilkins# | 1.750 | 1974 | |
| 97 | Rubén Vázquez | 1.753 | 1972 | |
| 97 | Harry Marquet# | 1.753 | 1981 | |
| 99 | Aubrey Gray# | 1.759 | 1978 | |
| 100 | Lee Bridges# | 1.761 | 1979 |
