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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Francisco Díaz | 101 | 1912-1916 | |
| 2 | Jesús Martínez | 78 | 1956-1962 | |
| 3 | Bob Corbin | 72 | 1966-1969 | |
| 4 | Sergio López# | 65 | 1985-1990 | |
| 5 | Jorge Ramírez# | 60 | 1989-1991 | |
| 6 | Russell Abbott | 58 | 1958-1963 | |
| 6 | Sergio Berrios | 58 | 1937-1941 | |
| 8 | Matt Logan | 55 | 1975-1979 | |
| 8 | Bastien Sanguinacco# | 55 | 1985-1986 | |
| 10 | Sergio Acevedo | 53 | 1963-1967 | |
| 11 | Eddie Webber | 51 | 1957-1963 | |
| 12 | Zachary King | 50 | 1911-1915 | |
| 13 | Jack Martin | 49 | 1962-1963 | |
| 14 | Lawrence Hudson | 47 | 1956-1958 | |
| 15 | Steve Lee | 45 | 1954-1959 | |
| 15 | Colm Longley | 45 | 1925-1932 | |
| 17 | Marvin Savage | 43 | 1967-1969 | |
| 17 | Félix Vázquez | 43 | 1950-1951 | |
| 19 | Ricardo Moya# | 42 | 1984-1985 | |
| 19 | Todd Walsh | 42 | 1935-1940 | |
| 21 | Glenn Lowery | 40 | 1980-1989 | |
| 22 | Caden Helton | 39 | 1963-1965 | |
| 23 | David Cheslin | 36 | 1912-1914 | |
| 23 | Norogumi Matsui | 36 | 1916-1921 | |
| 23 | Alfredo Romero | 36 | 1983-1989 | |
| 23 | Luke Todd | 36 | 1949-1958 | |
| 23 | Aurelio Valderrama | 36 | 1963-1966 | |
| 28 | Tim Koremans | 35 | 1911-1914 | |
| 29 | Juan García | 34 | 1954-1956 | |
| 30 | Michael Jones | 33 | 1912-1918 | |
| 30 | Brian Morris | 33 | 1914-1917 | |
| 32 | Víctor Padilla | 32 | 1913-1913 | |
| 33 | David Moore | 31 | 1913-1918 | |
| 34 | Bryan Bailey | 30 | 1955-1956 | |
| 34 | Enrique Diéguez# | 30 | 1986-1987 | |
| 34 | Joe Hyde | 30 | 1957-1959 | |
| 34 | Francisco Orellamo# | 30 | 1986-1990 | |
| 34 | Greg Taylor | 30 | 1953-1957 | |
| 39 | Nick Daniel | 28 | 1911-1912 | |
| 39 | Enea Frassetto | 28 | 1938-1945 | |
| 39 | Liangde Hann | 28 | 1916-1920 | |
| 39 | Nick Howard | 28 | 1966-1967 | |
| 39 | Borivoj Janku | 28 | 1975-1976 | |
| 39 | Félix Méndez | 28 | 1961-1963 | |
| 39 | Forrest Pollock | 28 | 1976-1981 | |
| 39 | Héctor Rivera | 28 | 1949-1954 | |
| 47 | Michael Halliburton | 27 | 1915-1916 | |
| 47 | Don Harper | 27 | 1966-1972 | |
| 47 | Luis Mota# | 27 | 1984-1991 | |
| 47 | Richard Vaughn | 27 | 1938-1941 | |
| 51 | Roberto Aponte# | 26 | 1982-1990 | |
| 51 | Ernesto Gámez | 26 | 1977-1983 | |
| 51 | Luis Quintero | 26 | 1970-1974 | |
| 54 | Tomás Cruz | 25 | 1965-1968 | |
| 54 | Ernesto Cuellar | 25 | 1946-1958 | |
| 54 | Luis Díaz | 25 | 1954-1954 | |
| 54 | Dante López | 25 | 1982-1990 | |
| 58 | Arthur Andrieux | 24 | 1969-1969 | |
| 58 | Jeff Dougherty | 24 | 1988-1988 | |
| 60 | Warren Bertrand | 23 | 1976-1977 | |
| 60 | Alfonso García | 23 | 1967-1974 | |
| 60 | Jeremiah Jackson | 23 | 1925-1928 | |
| 60 | Manuel Moreno# | 23 | 1985-1991 | |
| 60 | Phil Parrish | 23 | 1969-1971 | |
| 60 | Troy Riley# | 23 | 1982-1984 | |
| 66 | Alonso Álvarez | 22 | 1917-1927 | |
| 66 | Justin Bennett | 22 | 1945-1947 | |
| 66 | Wilson Bush | 22 | 1915-1917 | |
| 66 | Silvio Coppens | 22 | 1936-1939 | |
| 66 | Michael Hobby | 22 | 1911-1913 | |
| 66 | Manuel Muñóz | 22 | 1952-1962 | |
| 66 | Charlie Reid# | 22 | 1985-1991 | |
| 66 | Ramón Roa | 22 | 1966-1967 | |
| 74 | Bill Benson | 21 | 1937-1938 | |
| 74 | Rubén Díaz | 21 | 1952-1954 | |
| 74 | Bill Erlam | 21 | 1976-1987 | |
| 74 | Ismael Gamboa | 21 | 1950-1951 | |
| 74 | Bobby Green | 21 | 1915-1917 | |
| 74 | Javier Gutiérrez | 21 | 1940-1942 | |
| 74 | Harry Jones | 21 | 1983-1985 | |
| 74 | Dave Jordan | 21 | 1947-1950 | |
| 74 | Ken McDonald | 21 | 1911-1912 | |
| 74 | Teruo Takata | 21 | 1950-1955 | |
| 74 | Pat Watson | 21 | 1911-1911 | |
| 85 | John Andrés# | 20 | 1984-1984 | |
| 85 | Alex Borg | 20 | 1911-1916 | |
| 85 | Kevin Burt | 20 | 1948-1952 | |
| 85 | Carlos González | 20 | 1975-1976 | |
| 85 | Jerry Gore | 20 | 1977-1985 | |
| 85 | Jorge López | 20 | 1964-1967 | |
| 85 | Jason McDonald | 20 | 1911-1917 | |
| 85 | Domingo Sánchez | 20 | 1938-1942 | |
| 85 | Vicente Téllez | 20 | 1911-1914 | |
| 85 | Lee Wilson | 20 | 1912-1913 | |
| 95 | Herman Hancock | 19 | 1955-1960 | |
| 95 | Scott Kennedy | 19 | 1915-1917 | |
| 95 | Mike Lajoie | 19 | 1936-1939 | |
| 95 | Tade Noussen | 19 | 1963-1971 | |
| 95 | Fernando Quiñonez | 19 | 1955-1961 | |
| 100 | Víctor Barrios | 18 | 1949-1950 |
