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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Robert Jones | 95 | 1977-1981 | |
| 2 | Juan Escobar | 80 | 1978-1983 | |
| 3 | Manny Garza | 68 | 1911-1916 | |
| 4 | Bryan Schmidt | 62 | 1911-1915 | |
| 5 | Francisco Romero# | 54 | 1983-1985 | |
| 6 | Jason Garrett | 53 | 1916-1920 | |
| 7 | Howard Hamilton | 44 | 1948-1949 | |
| 8 | Alfredo González | 43 | 1936-1946 | |
| 9 | Juan Ramos | 42 | 1913-1916 | |
| 10 | José Montero | 41 | 1958-1960 | |
| 10 | Francisco Pereira | 41 | 1955-1957 | |
| 12 | Tim Thackray# | 39 | 1988-1989 | |
| 13 | Luis Morales# | 38 | 1988-1991 | |
| 14 | Ethan Opie | 37 | 1956-1959 | |
| 15 | Júlio Antúnez | 36 | 1945-1948 | |
| 15 | Darrell McCarty# | 36 | 1983-1987 | |
| 17 | Mike Wiggins# | 35 | 1976-1991 | |
| 18 | Vicente Aguilera | 34 | 1911-1911 | |
| 18 | Drake Day# | 34 | 1981-1982 | |
| 20 | Roberto Cruz | 31 | 1979-1988 | |
| 20 | Bob Sweet | 31 | 1913-1914 | |
| 22 | Carlos Hernández# | 30 | 1986-1988 | |
| 23 | Octávio Marés# | 29 | 1984-1988 | |
| 23 | Conan Mercer | 29 | 1911-1915 | |
| 25 | Mitch Brashear# | 28 | 1977-1981 | |
| 25 | Carl Case# | 28 | 1989-1991 | |
| 25 | Carlos Lozano | 28 | 1979-1982 | |
| 25 | Tade Noussen | 28 | 1959-1972 | |
| 29 | Salvador García | 27 | 1925-1928 | |
| 29 | Sam Mohmand | 27 | 1926-1928 | |
| 29 | António Prieto | 27 | 1931-1933 | |
| 32 | Enrique Calderón | 26 | 1952-1954 | |
| 32 | Christian Parent | 26 | 1966-1969 | |
| 32 | Rafael Proenza# | 26 | 1976-1989 | |
| 32 | José Reyes | 26 | 1953-1954 | |
| 36 | Mitch Davenport# | 25 | 1975-1976 | |
| 36 | Shunsuke Kato | 25 | 1950-1953 | |
| 36 | Isaac Love | 25 | 1957-1958 | |
| 36 | Danny Lyttle | 25 | 1947-1949 | |
| 36 | Christian McDougall# | 25 | 1986-1989 | |
| 36 | Juan Pérez# | 25 | 1981-1982 | |
| 36 | Dave Roy | 25 | 1915-1921 | |
| 36 | Sotan Wakabayashi | 25 | 1950-1958 | |
| 44 | Augusto García | 24 | 1960-1961 | |
| 44 | Luis Gómez# | 24 | 1987-1989 | |
| 44 | Marvin Harris | 24 | 1974-1979 | |
| 44 | Eugenio Sousa | 24 | 1957-1963 | |
| 44 | Neal Wibberley | 24 | 1963-1964 | |
| 49 | Colby Cunningham | 23 | 1966-1969 | |
| 49 | Chris Flowers# | 23 | 1987-1990 | |
| 49 | Carlos Ramos | 23 | 1916-1917 | |
| 52 | Bob Browne# | 22 | 1981-1984 | |
| 52 | Jesús Galló | 22 | 1954-1955 | |
| 52 | Fernando Garza# | 22 | 1988-1990 | |
| 52 | Chris Johnson | 22 | 1976-1978 | |
| 52 | Julián Martínez | 22 | 1982-1989 | |
| 52 | Ángel Mata | 22 | 1911-1912 | |
| 52 | José Medrano | 22 | 1950-1950 | |
| 52 | Elmer Schmidt | 22 | 1950-1954 | |
| 52 | Chris Winston | 22 | 1919-1923 | |
| 61 | Millard Arnold | 21 | 1977-1987 | |
| 61 | Dan Haines | 21 | 1967-1968 | |
| 61 | Gary Hubbard | 21 | 1955-1956 | |
| 61 | Shawn Kuoppala | 21 | 1960-1961 | |
| 61 | Tony Richardson | 21 | 1951-1952 | |
| 61 | Jorge Solís | 21 | 1940-1941 | |
| 67 | Ted Drain | 20 | 1969-1973 | |
| 67 | Munenori Hirose | 20 | 1950-1958 | |
| 67 | Lawrence James | 20 | 1917-1921 | |
| 67 | Mark Kelly | 20 | 1912-1915 | |
| 67 | Víctor López | 20 | 1946-1949 | |
| 67 | Lúcio Morales | 20 | 1949-1950 | |
| 73 | Travis Brown | 19 | 1952-1952 | |
| 73 | Mike Carson | 19 | 1917-1920 | |
| 73 | Enrique Fernández# | 19 | 1985-1986 | |
| 73 | John Giles | 19 | 1959-1960 | |
| 73 | Roberto Guillén | 19 | 1952-1954 | |
| 73 | Howard Hoskins | 19 | 1937-1937 | |
| 73 | Craig Peters | 19 | 1912-1915 | |
| 73 | Tomás Romero | 19 | 1940-1941 | |
| 73 | Nicky Studley | 19 | 1916-1917 | |
| 82 | Dewey Booker | 18 | 1978-1978 | |
| 82 | Stephen Coinneach | 18 | 1975-1987 | |
| 82 | Cristián Gallardo | 18 | 1947-1948 | |
| 82 | Félix García | 18 | 1917-1920 | |
| 82 | Will Hernández | 18 | 1975-1982 | |
| 82 | Jeff McDaniel# | 18 | 1979-1981 | |
| 82 | José Reyes | 18 | 1941-1946 | |
| 82 | Domingo Vargas | 18 | 1914-1920 | |
| 82 | Wu-shun Xiao# | 18 | 1982-1990 | |
| 91 | Juan Acevedo | 17 | 1961-1962 | |
| 91 | Eddie Brandt | 17 | 1964-1973 | |
| 91 | Sergio Díaz | 17 | 1930-1931 | |
| 91 | Jesse Ford | 17 | 1954-1957 | |
| 91 | Kevin Johnston | 17 | 1920-1921 | |
| 91 | Ramón Martínez | 17 | 1975-1977 | |
| 91 | Tony Pérez | 17 | 1981-1985 | |
| 91 | José Trevino | 17 | 1953-1954 | |
| 91 | Casper Versaal | 17 | 1948-1954 | |
| 91 | José Zamora# | 17 | 1986-1990 |
